Hormones and Cardiovascular Disease
Director: Pierre-Yves Scarabin

Hormones and Cardiovascular Disease
Director: Pierre-Yves Scarabin

Hormones and Cardiovascular Disease
Director: Pierre-Yves Scarabin

 

The Hyperstar Project aims to investigate the predictive value of haemostatic variables and sex hormones measurement in assessing cardiovascular risk in th elderly. We use the data from the Three-City (3C) cohort study. The 3C study is a prospective cohort study constituted of 9294 non-institutionalized subjects (3649 men and 5645 women), aged 65 years and over, who were recruited from the electoral rolls of 3 French cities (Bordeaux, Dijon and Montpellier).

After a 4-year follow-up, a case-cohort study was designed including about 500 incident  cases of cardiovascular disease (coronary heart disease ans stroke) and /or dementia and a random sample of 1 200 subjects. Haemostatic variables (thrombin generation test, fibrinogen, von Willebrand factor, D-Dimer...) and sex hormones ( total and bioavailable estradiol and testosterone, sex hormone-binding globulin (SHBG)..) are measured in plasma samples collected at baseline and stored at -80°C. Thrombogenic mutations as well as sex hormones receptors genotypes are also investigated.

This project was set up in collaboration with the Laboratory of Paris XI University (Anne Guiochon-Mantel) and Haematology Laboratory of HEGP and inserm U428 (Joseph Emmerich, Martine Alhenc-Gélas, Pascale Gaussem).

© Esther 2019