Hormones and Cardiovascular Disease
Director: Pierre-Yves Scarabin

 

Hormones and Cardiovascular Disease
Director: Pierre-Yves Scarabin

 

Hormones and Cardiovascular Disease
Director: Pierre-Yves Scarabin

 

Frailty is an emerging concept in the area of ageing. This clinical syndrome is characterized by an accumulation of physical and cognitive deficits that may lead to disability.

During her postdoctoral position, Laure Carcaillon investigated plasma sex hormones in relation to frailty among postmenopausal women aged > 70 yrs. She used data from the Toledo Study for Healthy Aging, a Spanish population-based cohort study conducted by Leocadio Rodríguez-Mañas. She showed that higher estradiol levels were associated with frailty in postmenopausal women. In addition, women with both higher estradiol and C reactive protein were particularly at high risk, suggesting interrelationships between estradiol, inflammation and frailty.

These results are published in the Journal of Clinical Endocrinology and Metabolism and they provide further evidence that high endogenous estradiol levels may have adverse effects on clinical outcomes among older postmenopausal women.

© Esther 2019