Hormones and Cardiovascular Disease
Director: Pierre-Yves Scarabin

 

Hormones and Cardiovascular Disease
Director: Pierre-Yves Scarabin

 

Hormones and Cardiovascular Disease
Director: Pierre-Yves Scarabin

 

Low plasma testosterone has been consistently related to increased all-cause mortality in men. However, the question of whether changes in endogenous testosterone levels play a role in the development of athero-thrombosis remains largely unsolved.

During her PhD thesis, Véronique Soisson investigated the role of endogenous sex hormones in the development of ischemic arterial disease in men using the data from the three-City (3C) study, an ongoing French longitudinal multicentre study among 10 000 subjects aged 65 and over. She showed that both high and low plasma testosterone levels were associated with an increased risk of  ischemic arterial disease, including coronary heart disease and ischemic stroke. This J-shaped relationship was independent of traditional cardiovascular risk factors. Results have been published in Maturitas.

Optimal range of plasma testosterone may confer cardiovascular protection among men in the elderly and these results may have clinical implications in the management of testosterone deficiency.

© Esther 2019