Hormones and Cardiovascular Disease
Director: Pierre-Yves Scarabin

 

Hormones and Cardiovascular Disease
Director: Pierre-Yves Scarabin

 

Hormones and Cardiovascular Disease
Director: Pierre-Yves Scarabin

 

 

Among postmenopausal women with carotid atherosclerosis who participated to the Rotterdam Study, high levels of circulating estradiol were associated with both increased likelihood of having unstable carotid plaque and increased risk of stroke. These data published in Circulation Research are remarkably consistent with our previous findings from the Three City Cohort (3C) Study showing that high level of plasma estradiol emerged as a new predictor of ischemic arterial disease in older postmenopausal women. The results of these two cohort studies reinforce the timing hypothesis which assumes harmful effects of estrogens in the elderly among women with underlying atherosclerosis in contrast to protective vascular effects in healthy younger women. See our Letter to the Editor.

© Esther 2019